Hao-Chi Hsu

Structure − Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors

Cryo-EM structural studies reveal a novel binding pose of the inhibitor at the Pf 20S β 5 active site, explaining the enhanced activity of an N -cap sulfonamide modification compared to an N -cap amide, and offer insights into the development of next-generation antimalarial Pf 20S-targeting compounds with improved drug...