Author

Hao Deng

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Open access Sep 2026

Transcriptome Sequencing Reveals Molecular Characteristics of Spinal Cord Degeneration in MPTP-Induced Parkinson’s Disease Mice

Simple Summary Parkinson’s disease (PD) is the second most common neurodegenerative disorder globally. Its pathological lesions are not restricted to dopaminergic neurons in the substantia nigra but also involve distal tissues such as the spinal cord. However, the molecular mechanisms of spinal cord degeneration remain...

Ling-Long Xiao, Ya-Ping Wu, Xin-Yu Huang et al. · Biology · 0 citations

Review Open access Oct 2026

Deep brain stimulation as neuroimmune-metabolic modulation in Parkinson’s disease and beyond: tissue response, glial remodeling, and disease modification

Deep brain stimulation (DBS) is an established symptomatic therapy for Parkinson’s disease (PD), yet its biological effects extend beyond modulation of abnormal basal ganglia circuitry. This review conceptualizes DBS in PD as a neuroimmune-metabolic intervention acting across the electrode-tissue interface, glial netwo...

Hao Deng, Xiao-Long Li, Di Wang et al. · Frontiers in Immunology · 0 citations