Author

Hao-Dong Xu

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Open access Sep 2026

PTEN-L inhibits mitophagy and GSDME-dependent pyroptosis via Parkin dephosphorylation.

Mitochondrial dysfunction is a potent trigger of inflammatory cell death; however, the precise signaling pathways linking mitochondrial damage to pyroptosis remain incompletely understood. Here, we identify a previously unrecognized pathway in which mitochondrial depolarization activates the PINK1-Parkin axis to drive...

Cheng-Hao Yan, Cai-Nian Huang, Xu Liu et al. · EMBO Reports · 0 citations

#generative ai Review Open access Sep 2026

Generative AI-enabled neoantigen vaccine engineering: From tumor antigen discovery to personalized construct design and translational validation.

How generative AI may broaden the computational scope of tumor-anchored antigen discovery, support tumor-context-integrated optimization of neoantigen candidates, facilitate the engineering of multi-epitope and mRNA vaccine constructs, and incorporate tumor-specific constraints such as antigen-presentation defects, clo...

Xin-Jie Hu, Xin-Yu Liu, Tao Wang et al. · Biotechnology Advances · 0 citations