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Author

Haohan Wang

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Open access Sep 2026

Stratifying Alzheimer’s disease by patient-specific genetic signatures reveals cognition-linked and cross-disease heterogeneity

Alzheimer’s disease (AD) presents profound clinical and genetic heterogeneity that obscures its biological underpinnings and impedes therapeutic development. While genome-wide studies have identified population-level risk loci, the architecture of patient-specific genetic variation and its link to clinical outcomes rem...

Jia-Hui Zhang, Zi-Yu Yu, Xing-Cai Zhang et al. · 0 citations
Review Aug 2026

AI-powered medicinal chemistry and translational drug development.

This review examines how machine learning, deep learning, natural language processing (NLP), and generative modeling are being applied across medicinal chemistry and drug development, and highlights how multimodal data fusion, predictive modeling, and human-AI collaborative frameworks are supporting more informed decis...

Kaicheng U, Sophia Meixuan Zhang, Ziyu Yu et al. · 0 citations

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