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Author

Hao-Lin Tang

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Review Open access Sep 2026

HIV-driven tumor ecosystem: from chronic immune dysfunction to cancer evolution

Although HIV-associated malignancies have been reviewed separately through the lens of individual oncogenic viruses (KSHV, EBV, HPV) or immune dysfunction in isolation, no prior synthesis has integrated these processes into a single, systemic “tumor ecosystem” framework spanning virology, immunology, the tumor microenv...

Guang Zhou, Juan-Yan Liao, Hao-Lin Tang et al. · 0 citations
Jul 2026

Structure-Guided Optimization of p62-Directed AUTOTACs for Efficient EGFR/VEGFR2 Degradation and Antitumor Efficacy.

Receptor tyrosine kinases (RTKs) are core cancer therapeutic targets, yet their integral membrane localization hinders efficient degradation by traditional ubiquitin-proteasome system (UPS)-based targeted protein degradation (TPD) strategies. Herein, we describe the structure-guided development of p62/SQSTM1-directed a...

Defa Wu, Yongya Wu, Min Zhao et al. · 0 citations

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