Open access
Aug 2026
Benchmarking cell type annotation in spatial transcriptomics: resolving cellular hierarchies, biological fidelity, and dynamic cell states
A comprehensive, context-specific guide to current annotation strategies for spatial transcriptomics is presented and open-set recognition of reference-absent cell states, adaptive incorporation of spatial context, and improved resolution of rare and transitional cell identities are identified as central priorities for...
Yu-Ling Zhu, Yunfei Hu, M. Xie et al.
· Research Square · 0 citations