SND1 promotes colorectal cancer progression and metastasis by stabilizing HK2 through the inhibition of FBW7-mediated ubiquitination.
BACKGROUND Metabolic reprogramming, particularly enhanced aerobic glycolysis, is a hallmark of colorectal cancer (CRC) progression and metastasis. However, the key regulatory mechanisms linking glycolytic remodeling to metastatic progression remain incompletely understood. METHODS We integrated single-cell RNA sequen...