Hao-Rong Li

Constructing cell-type-specific gene regulatory networks from cell–cell communication and a global gene regulatory network

Abstract Accurately inferring cell-type-specific gene regulatory networks (GRNs) is crucial for understanding cellular heterogeneity, lineage determination, and disease progression mechanisms. Although single-cell RNA sequencing (scRNA-seq) enables high-resolution expression profiling, its inherent sparsity and high no...