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Hao-Sheng Feng

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Review Open access Aug 2026

Ultrahigh-DAR antibody–drug conjugates: advancing the next generation of targeted therapy

Abstract Conventional antibody–drug conjugates (ADCs) are typically limited to drug-to-antibody ratios (DARs) of ≤8 because of restricted conjugation sites and unfavorable physicochemical properties at higher DARs, including increased hydrophobicity, aggregation, and rapid systemic clearance. Consequently, most clinica...

Hao-Sheng Feng, Bin Liu · 0 citations

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