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Open access Sep 2026

Association between BDNF methylation and expression of the NLRP3 inflammasome in the brain is disrupted in Alzheimer’s disease

Activation of the NLRP3 inflammasome pathway and dysfunction of brain-derived neurotrophic factor (BDNF) are both implicated in the pathogenesis of Alzheimer’s disease (AD). While in vitro and in vivo models support these mechanisms, there is little research investigating their relationship in human brain tissue, and w...

Hao Tang, H. Fachim, M. Harte et al. · 0 citations

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