Hao-Tian Cao

Decoding neuro-tumor interactions in pancreatic cancer: mechanisms, immunosuppressive networks and therapeutic opportunities

A unified four-stage mechanistic model of PNI is proposed, encompassing mutual chemotaxis between tumors and nerves, adhesion and invasion at the tumor-nerve interface, extracellular matrix remodeling, and neural plasticity alterations, and defines the perineural invasion microenvironment as a neuro-immune privileged s...