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Open access Sep 2026

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

ABSTRACT Peripherally restricted analgesics devoid of central side effects are urgently needed for postoperative pain management. The cannabinoid type‐1 receptor (CB1R) expressed on primary sensory neurons represents an attractive peripheral target, yet its specific role and mechanism in postoperative pain remain poorl...

Kang-Tai Xu, Lu-Yao Ji, Hao-Yi Yang et al. · 0 citations
Sep 2026

ALKBH5-Dependent m6A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration.

BACKGROUND N6-methyladenosine (m6A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m6A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent dioxygenase AlkB homolog 5), an m6A demethylase,...

Kun Liu, Chi-Qian Liang, Hong-Ji Li et al. · 0 citations

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