Author

Hao Wang

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Open access Sep 2026

Tumor mutational burden as a prognostic biomarker for survival and quality of life in metastatic colorectal cancer patients receiving anti-PD-1/PD-L1 immunotherapy

The aim of this study was to assess the prognostic value of tumor mutational burden (TMB) as a biomarker for metastatic colorectal cancer (mCRC) in patients receiving immunotherapy-containing regimens. This retrospective cohort study analyzed 221 patients with mCRC. From January 1, 2020 to December 31, 2021, patients d...

Wen-Ming Yuan, Hao Wang, Xiu-Feng Wang · Medicine · 0 citations

Open access Sep 2026

Biomimetic arsenic trioxide nanoplatform induces Caspase-3/GSDME pyroptosis and remodels the glioma immune microenvironment

Glioma (GBM) is characterized by severe invasiveness and grim clinical outcomes. The therapeutic efficacy of conventional treatments is severely constrained by the blood-brain barrier (BBB), while the immunosuppressive tumor microenvironment (TME) further compromises treatment responsiveness. In GBM, abnormal expre...

Hao Wang, Sen-Sen Zheng, Ding-Feng Chen et al. · Nano Reseach · 0 citations