Hao Wang

Topology-adjusted knockout (TAKO): interpretable in silico single-gene knockout ranking on wild-type single-cell gene regulatory networks

Predicting single-gene knockout effects from wild-type single-cell RNA-seq data remains challenging when perturbation experiments are costly and existing approaches require knockout-specific model training. Here we introduce Topology-Adjusted Knockout (TAKO), a computationally efficient WT-only framework for single...