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Sep 2026

Gut microbiota-mediated dietary lignans metabolism drives accumulation of N,N-dimethylsphingosine and sensitizes triple-negative breast cancer to paclitaxel.

For triple-negative breast cancer (TNBC), which lacks specific therapeutic targets, paclitaxel (PTX) chemotherapy remains the first-line clinical treatment. However, the widespread issue of treatment resistance severely limits its effectiveness, making it urgent to explore safer and more effective chemosensitization st...

Jian-Yu Wang, Liu-Ying Zhao, Shi-Lu Zhao et al. · 0 citations
Aug 2026

Targeted Degradation of ATP7B via a Novel Autophagy-Targeting Chimera Promotes Cuproptosis to Potentiate Anti-Tumor Immunity in Clear Cell Renal Cell Carcinoma.

The RNF186-p62-ATP7B axis is identified as a critical regulator of copper homeostasis in ccRCC and Targeting ATP7B via ATAUTAC offers a potent strategy to induce cuproptosis and sensitize ccRCC to immunotherapy.

Muyang Cao, Zhenkun Dong, Yang-Yang Xu et al. · 0 citations

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