Author

Hao Wu

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Oct 2026

Juglone induces GSDME-mediated pyroptosis by targeting HSP90α ATPase domain to promote STAT3 degradation in glioblastoma multiforme.

Glioblastoma (GBM) is a highly aggressive primary brain tumor with grim overall median survival, and its therapeutic efficacy is severely limited due to drug resistance. Therefore, developing effective and safe chemotherapy regimens is urgently required. Juglone, a natural bioactive constituent derived from traditional...

Hao Wu, Shuai Chen, Jia-Wen Li et al. · Toxicology and Applied Pharm... · 0 citations

Review Open access Aug 2026

Hyaluronic acid-based nanocarriers for cancer therapy: molecular design, biointerface mechanisms, and translational challenges

This review examines studies published from 2019 to 2026, and connects the structural parameters of HA with quantitative drug delivery efficiency and therapeutic performance, and summarizes the current design principles of HA-based nanocarriers while critically discussing the remaining challenges.

Hao Wu, P. Snetkov, Jing-Ran Zhang et al. · Nanotechnology · 0 citations