Author

Hao Yang

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Open access Jul 2026

Discovery of spirocyclic amide scaffolds as novel neddylation E1 inhibitors to suppress the growth and survival of lung cancer cells.

Compound 24 (HA-218-6-31-80) represents a promising NAE inhibitor, offering a potential therapeutic candidate for lung cancer and a novel scaffold for neddylation targeted drug discovery.

Qiuxun Chen, Jiezhen Zhuo, Changxin Zhong et al. · RSC Medicinal Chemistry · 0 citations