Haoran Shen

Spatially confined programmable DNA hydrogel scaffolds accelerate Cas12a trans-cleavage for digital bioimaging.

Molecule diffusion limits target detection in conventional homogeneous solution, typically resulting in inefficient target-probe collision efficiency, low reaction kinetics, and insufficient signal accumulation. Herein, a dual rolling circle amplification-based DNA hydrogel was constructed to establish a hydrogel confi...