7,8-dihydroxyflavone exerts neuroprotective effects against traumatic brain injury in mice via the TrkB-dependent anti-ferroptotic ERK/CREB/GPX4 pathway.
Traumatic brain injury (TBI) triggers severe secondary brain damage with ferroptosis as a key driver. 7,8-dihydroxyflavone (7,8-DHF), a selective TrkB agonist, has known neuroprotective properties, yet its regulatory role in TBI-related ferroptosis remains unclear. This study aimed to explore whether 7,8-DHF alleviates...