Oct 2026
Genetic modulation of NAD(P)H homeostasis reveals distinct redox-coupled metabolic vulnerabilities.
Xing-Xiu Pan, Austin L. Zuckerman, Karl N. Miller et al.
· Nature Metabolism · 0 citations
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Open access
Sep 2026
MCT1 activity defines an aggressive metabolic phenotype and therapeutic target in non-small cell lung cancer
Lactate uptake through monocarboxylate transporter 1 (MCT1) is associated with aggressive disease in non-small cell lung cancer (NSCLC), but how lactate transport supports tumor metabolism remains incompletely understood. Integrating stable isotope tracing, metabolomics, and transcriptomics across patient tumors, anima...
Robert B. Cameron, Kristen E. Shema, Nathan Dubois et al.
· bioRxiv · 0 citations
Open access
Aug 2026
Galanin impairs tumor immunity in glioblastoma by promoting infiltration and ferroptosis resistance of myeloid-derived suppressor cells
Glioblastoma (GBM) is a highly aggressive and lethal form of brain tumor that resists immunotherapy. Here we show that neuropeptide galanin (GAL) drives immunosuppression and immunotherapy resistance in GBM. Mechanistically, GBM cell-secreted GAL interacts with its receptor GALR3 on monocytic myeloid-derived suppressor...
Lizhi Pang, Yang Liu, Fei Zhou et al.
· Nature Cancer · 0 citations