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Author

Harrison B. Taylor

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Open access Aug 2026

Hyperglycemia and Alteration in Sphingolipids Are Early Mediators of Diabetic Kidney Disease: Role of Elongase 1

Abstract Introduction Diabetic kidney disease (DKD) is characterized by impairment of renal glomerular and tubular cells. Low plasma levels of ceramides and lactosylceramides containing very long-chain (VLC) fatty acid were found to be predictive of DKD development. Elongase 1 (Elovl1) is a ubiquitous elongase that elo...

W. Twal, P. Angel, K. Helke et al. · 0 citations
Aug 2026

A Protocol for Multivariate Data Visualization and Pseudotime Modeling for Analysis of Disease Trajectories Detected by Mass Spectrometry Imaging.

Mass spectrometry imaging (MSI) has emerged as a powerful modality for spatially resolved molecular profiling of tumor and stromal compartments; however, computational frameworks for MSI data analysis lag significantly behind those developed for spatial transcriptomics, limiting its translational potential. Here, we in...

Bryn Gerding, Taylor S. Hulahan, Laura Spruill et al. · 0 citations

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