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Author

Haruhiko Koseki

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Open access Aug 2026

SPIN1 selectively silences evolutionarily young transposable elements through chromatin regulation

SPIN1 uses a histone-state-based mechanism to identify and repress young TEs in pluripotent cells, mechanistically distinct from its germline mode in which SPIN1 cooperates with the PIWI–piRNA pathway to promote DNA methylation, illustrating how a single histone reader engages distinct silencing machineries across cell...

Hiromi Yamada, Chikara Takeuchi, Clive S. Barker et al. · 0 citations

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