Open access
Sep 2026
Synthesis and in silico studies of hexahydroacridine derivatives as potential antitumor agents
The anticancer potential of newly synthesized hexahydro-1,8-acridinedione derivatives featuring strategic structural modifications at positions 9 and 10 is evaluated, establishing compound 4d as a promising multi-target lead scaffold, warranting further optimization toward selective anticancer therapeutics.
E. El-Helw, S. Hammad, Hassan A. Khatab et al.
· Scientific Reports · 0 citations