PIWI-Interacting RNAs: Biogenesis, Molecular Mechanisms, Computational Advances, and Roles in Human Health and Disease.
PIWI-associated RNAs (piRNAs) are a diverse and abundant class of small regulatory non-coding RNAs that play central roles in genome regulation and transposon silencing. First identified in germline cells, piRNAs are now also implicated in somatic cell function, stem cell maintenance, immunity, and human disease, parti...