Open access
Oct 2026
QbD aided optimization and molecular docking of pH-sensitive hydrogels for targeted colon delivery in ulcerative colitis
Oral formulations of aminosalicylates are widely used in the treatment of ulcerative colitis (UC), but their efficacy is limited by low absorption and bioavailability due to first-pass metabolism and gastric degradation. pH-sensitive hydrogels were formulated for colon-targeted, delayed drug release to address this con...
Muhammad Zeeshan Shamshair, Waqar Siddique, Muhammad Zaman et al.
· RSC Advances · 0 citations