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Hayden Fisher

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Open access Aug 2026

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition

In bacteria, DnaB replicative helicases are essential for unwinding genomic DNA to provide the single‐stranded templates required for replication. The recruitment of the hexameric DnaB helicase to the origin of replication is mediated by distinct mechanisms that rely on specialized factors known as helicase loaders. Th...

Daniele Mazzoletti, Andrea Garavaglia, Hayden Fisher et al. · 0 citations
Open access Jul 2026

Carbonara: a SAXS-guided seeding framework for exploring protein solution-state dynamics

Carbonara is presented, a framework that uses experimental small-angle X-ray scattering (SAXS) data to predict alternative physically plausible protein conformations and provides a route from static structural models of flexible multi-domain proteins and multimeric assemblies to solution-state ensembles.

Josh McKeown, Cameron Brown, Arron Bale et al. · 0 citations

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