Hypoxia stabilizes HIF-1a and HIF-2α, which cooperate with multiple epigenetic regulators, including DNA methyltransferases, histone-modifying enzymes, chromatin remodelling complexes, and non–coding RNAs, which promote EMT, CSC maintenance, immune escape, metastasis, and resistance to chemotherapy and immunotherapy.
Yasamin Al-Qassab, Tharwa H. Al-Tai, Suha A. al-Fakhar et al.· Journal of the Faculty of Me...· 0 citations
Background. Mean platelet volume (MPV) is routinely reported in the complete blood count; however, its role in determining disease activity in systemic lupus erythematosus (SLE) remains unclear. Objectives. To explore the association between MPV and SLE disease activity and to assess whether MPV can distinguish active...
Zainab Khalid Khaleel, Amna Shaker Mahdi, Mustafa Jawad Al-Imari et al.· Romanian Journal of Rheumato...· 0 citations
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