Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications
The prognostic impact of type 2 diabetes in esophageal cancer patients receiving neoadjuvant therapy followed by surgery remains unclear. We evaluated its association with perioperative outcomes and long-term surv...
Xi-Peng Wang, Zhi-Chao Liu, Xue-Feng Leng et al.· Diseases of the esophagus· 0 citations
Bispecific antibodies (BsAbs) integrate two binding specificities to coordinate antitumor mechanisms that cannot be readily achieved with conventional monospecific antibodies. In lung cancer, these agents encompass four principal strategies: dual targeting of tumor-associated receptors, immune-cell redirection, simulta...
Ming-Yuan Du, Yi-Chao Han, Run-Sen Jin et al.· Critical reviews in oncology...· 0 citations
Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies
The clinical significance of supraclavicular lymph node (SCLN) involvement in esophageal cancer remains controversial. The role of surgery in managing patients with SCLN metastases remains uncertain. This study evaluates the prognostic outcomes of pati...
Yiheng Huang, Yuqin Cao, He-Cheng Li· Diseases of the esophagus· 0 citations
Insufficient T-cell infiltration is a major barrier to the efficacy of immune checkpoint inhibitors (ICIs) in lung adenocarcinoma (LUAD). We aimed to investigate how the tumor-intrinsic m5C methyltransferase NSUN2 shapes the immune landscape of LUAD. Nsun2 conditional knockout mice and syngeneic mice models were employ...
Wang-Yang Meng, Tong Lu, Ming-Yuan Du et al.· Experimental Hematology & On...· 0 citations
Regulatory T cells (Tregs) maintain immune homeostasis through FOXP3-centered transcriptional complexes that tightly control lineage stability and suppressive function. However, how specific FOXP3 mutations disturb this complex and drive pathogenic Treg reprogramming in IPEX syndrome remains unclear. We identifie...
Bin Li, Wei-Qi Zhang, Xin-Nan Liu et al.· Journal of Immunology· 0 citations
