Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.
BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory disorder characterized by persistent mucosal injury and disturbed immune-metabolic homeostasis. Increasing evidence indicates that metabolic remodeling of intestinal epithelial cells contributes to UC-associated inflammation; however, the key metabolic regula...