He-Huang Xie

A Phosphorylation-Independent Monoclonal Antibody Improves Detection of TDP-43 Pathology Across FTLD, ALS, and LATE-NC

TDP-43 proteinopathies encompass frontotemporal lobar degeneration with TDP-43 pathology (FTLD TDP), amyotrophic lateral sclerosis (ALS TDP), and limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE NC), all of which exhibit subtype-specific aggregate architectures that may constrain epit...