Human dermal fibroblast-derived exosomes attenuate UVB-induced photoaging phenotypes by reducing oxidative DNA damage and modulating PGC-1α/Nrf2 signaling.
BACKGROUND Aging, particularly photoaging induced by ultraviolet B (UVB) exposure, is characterized by oxidative DNA damage and extracellular matrix degradation. Exosomes are small vesicles secreted by cells and may mitigate oxidative stress and protect against photoaging. This study investigated the role of human derm...