Sep 2026
GSH-responsive nanoparticle drug delivery system for simultaneous blockade of CD73/A2AR to reverse adenosine-mediated immunosuppression.
The adenosine signaling pathway is a key mechanism of tumor immune evasion, collaboratively promoting immunosuppression through CD73-mediated adenosine production and A2AR-mediated signal transduction. This study designed and synthesized two novel conjugates, BSC and BSPC, which chemically link the CD73 inhibitor betul...
Chuan-Hao Wang, Yang-Yang Gong, Dao-Zuan Zhang et al.
· Biomaterials Advances · 0 citations