Temporal dysregulation of PPARG-PRKAG2 co-localization in gray matter: Implications for cognitive decline and intervention targets in type 2 diabetes.
PPARG-mediated metabolic remodeling and PRKAG2/AMPK-driven energy sensing may act as neuroprotective mechanisms in response to both pathological (T2DM) and normative (aging) contexts, potentially resulting in cognitive decline and increased risk for dementia.