Heather Geiger

DECONVersation: Single Cell Foundation Model-Derived Embeddings for Robust Cell Type Deconvolution of Bulk RNA-seq

AI and deep learning have transformed single-cell transcriptomics, empowering unsupervised annotation, trajectory inference, and cross-dataset integration at scale. Here, we propose bulk RNA-seq deconvolution as a novel task for single-cell foundation models. Deconvolution estimates cell type proportions from bulk RNA-...