Author

Hee-Seok Kweon

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Open access Sep 2026

Ursolic acid attenuates LPS-induced cognitive dysfunction through the modulation of oxidative stress, neuroinflammation, and hippocampal synaptic plasticity.

BACKGROUND Neuroinflammation and oxidative stress play vital roles in the pathogenesis of neurodegenerative diseases characterized by cognitive decline. Ursolic acid (UA), a natural pentacyclic triterpenoid compound with reported anti-inflammatory and antioxidant properties, has been suggested as a potential neuroprote...

Ga-Young Choi, Seohyeong Lee, A. Je et al. · Phytomedicine · 0 citations

Open access Aug 2026

Neuronal AIMP2–α-synuclein synergy drives endogenous tau and amyloid-β pathologies and neurodegeneration in a mechanistic model of Lewy body dementia

Lewy body dementia (LBD), encompassing Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), is defined by widespread α-synuclein (αSyn) aggregation and frequently exhibits coexistent tau and amyloid-β (Aβ) pathologies. However, whether αSyn pathology is sufficient to drive endogenous tau and Aβ agg...

Doeun Kim, Hee-Tae Kim, Ji Hun Kim et al. · Cell Death & Disease · 0 citations