mRNA-lipid nanoparticles (mRNA-LNPs) have revolutionized nucleic acid therapeutics, yet their clinical success relies heavily on precise manufacturing processes. This review comprehensively explores the critical intersection between microfluidic channel design, lipid self-assembly biophysics, and the subsequent biologi...
Hyejoong Jeong, Cheol Hui Park, Bookun Kim et al.· Lab on a Chip· 0 citations
One of the challenges in cardiac cell therapy using cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) is their poor engraftment and survival rate in infarcted tissues. Click chemistry and lipid insertion are simple methods for modifying the surface of hPSC-CMs with a collagen hybridizing peptide (CHP)...
Donghyun Lee, Woo-Sup Sim, Jae-Hyun Park et al.· Bioactive Materials· 0 citations
A synthetic ionizable lipid with a dual pKa property that is retained in formulated LNPs is introduced and it is shown that after intravenous injection, these dual pKa LNPs produce lung‐selective mRNA expression with higher potency than a cationic lipid‐rich comparator while remaining well tolerated.
Seong Gi Lim, Min-Ju Lee, Yiming Wang et al.· Advancement of science· 0 citations
A photochemistry-based ionizable lipid library (PILL) platform that enables the rapid discovery of ionizable lipids for mRNA delivery and provides a versatile framework for the development of next-generation LNP systems for nucleic acid therapeutics is reported.
Simin Chun, Hyorim Nam, Donghyun Lee et al.· Journal of the American Chem...· 0 citations
The combination of the Ce6/PP123 NCs with a novel wearable OLED is a promising platform for effective and safe PDT in cancer treatment and shows optimal spectral characteristics and the highest therapeutic efficacy in vitro.
Hyeryeon Oh, S. Jeong, Cheol Hui Park et al.· Advanced Healthcare Material...· 0 citations
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