Sep 2026
Rational Engineering of the Radical SAM Enzyme HtkB Expands the Chemical Space of Cyclophane RiPPs
Cyclophane-containing peptides represent a structurally diverse class of macrocycles with important applications in drug development due to their stability and target specificity. Radical S-adenosylmethionine (rSAM) enzymes are key catalysts for cyclophane formation and execute chemically challenging C(sp2)–C(sp3) cr...
Qian-Qian Guo, Yi Jia Low, Alicia Kaijun Poo et al.
· ACS Catalysis · 0 citations