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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Helge B. Bode

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2 papers indexed here

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Open access Sep 2026

Heterologous Reconstitution of 4-Amidopentadienoate Biosynthesis Identifies the PKS Machinery Responsible for Warhead Formation

The biosynthetic origin of the APD warhead is established and a foundation for incorporating this privileged pharmacophore into engineered peptide scaffolds is provided for incorporating this privileged pharmacophore into engineered peptide scaffolds.

M. Tvilum, Jonas L. Veiler, Thomas T. Paulsen et al. · 0 citations
Open access Aug 2026

Total Synthesis and Structural Revision of Rhabdobranin Reveals a Cryptic Gram-Negative Antibiotic

A convergent total synthesis of the proposed structure of pre-rhabdobranin B revealed a stereochemical misassignment at the N-terminal arginine residue, which validate resistance-gene-guided discovery in Gram-negative symbionts as a strategy for uncovering cryptic antibiotics and identify rhabdobranin as a promising sc...

Woonkee S. Jo, Zaynoun Attieh, Jan J. Crames et al. · 0 citations

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