Helle D. Ulrich

Trans-branching of polyubiquitin chains orchestrates the DNA replication stress response

Polyubiquitin chain geometry dictates functional consequences of ubiquitylation (1, 2). Although branched polyubiquitin chains are abundant in cells, little is known about their functions (3–5). Here we show that branching on the DNA replication factor PCNA, mediated by the ubiquitin-conjugating enzyme UBE2K and involv...