CloneOT: predicting clone-specific perturbation responses with lineage-supervised neural inverse optimal transport
CloneOT is a neural inverse OT method that learns both the transport cost and the transport map from partially lineage-traced single-cell datasets, and reveals the clone-specific transcriptional programs of drug-tolerant persister cells and forecasts the fate of each clone from its cells before treatment.
Yan-Shuo Chen, Wei Chen, Heng Huang
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