Preclinical evaluation of JQ1 in esophageal squamous cell carcinoma: growth and migration suppression with BRD4-associated DNA damage and apoptotic signaling
Background Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited therapeutic options. Bromodomain-containing protein 4 (BRD4), a BET family epigenetic reader, regulates oncogenic transcription and may represent a pharmacological vulnerability in ESCC. This study evaluated the pharmacologica...