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Author

Henrik Nielsen

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Open access Sep 2026

Signal peptidase complexes set species-specific rules for signal peptide cleavage

Protein secretion is essential for cell function and begins when signal peptides direct nascent proteins into the secretory pathway, where they are cleaved by the signal peptidase complex (SPC). Although this pathway is highly conserved, signal peptides do not always function efficiently across species, and the molecul...

Yeonji Chung, Gilberto P. Pereira, Young June Lee et al. · 0 citations
Open access Aug 2026

DeepTMHMM2 enables accurate prediction of transmembrane protein topology and subcellular location

DeepTMHMM2 is presented, the first predictor to include re-entrant regions and interfacial helices in its topologies and jointly predict localization across 17 biological membranes and Benchmark results show that DeepTMHMM2 successfully learns to predict the additional elements, while achieving strong performance on ca...

Felix Teufel, Jeppe Hallgren, Henrik Nielsen et al. · 0 citations

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