Hersa Milawati

Recent advances in the precision synthesis of homogeneous N-linked glycoproteins: Synthetic strategies and discovery of latent functions.

Protein glycosylation crucially regulates the function and stability of mammalian membrane and secreted proteins. However, because biological glycan processing is inherently a non-template-driven process, natural glycoproteins exist as heterogeneous mixtures. This structural heterogeneity has historically hindered the...