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Author

Hetal P. Patel

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2 papers indexed here

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Open access Sep 2026

Central Composite Design-Optimized Dabigatran Etexilate Cubosomes for Sustained Oral Release and Enhanced In Vivo Pharmacokinetics.

OBJECTIVES Dabigatran etexilate mesylate (DEM), a prodrug of the direct thrombin inhibitor dabigatran used for stroke prevention in nonvalvular atrial fibrillation, exhibits poor aqueous solubility, P-glycoprotein-mediated efflux, and limited oral bioavailability, which pose challenges for oral delivery. This study aim...

Aashka H. Bhatt, Hetal P. Patel, Parvez S. Shaikh et al. · 0 citations
Open access Sep 2026

Engineered polymeric nanosponge in-situ gel enables sustained and enhanced nose-to-brain delivery of quetiapine fumarate.

Quetiapine fumarate is a second-generation antipsychotic with limited oral bioavailability owing to extensive hepatic first-pass metabolism, making it a suitable candidate for intranasal brain delivery. This study aimed to develop a quetiapine fumarate-loaded nanosponge in-situ gel for sustained and enhanced brain deli...

Priyanshi R. Patel, Aashka H. Bhatt, Hetal P. Patel et al. · 0 citations

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