ABSTRACT In immunocompromised patients, persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries the risk of prolonged viral shedding and emergence of new variants. To reproduce the key features of persistent SARS-CoV-2 infection and evaluate its transmissibility, mouse-passaged SARS-Co...
Kaya Miyazaki, Nozomi Shiwa-Sudo, N. Iwata-Yoshikawa et al.· Microbiology spectrum· 0 citations
It is revealed how PA-X modulates the cellular environment while sparing the viral genome to favor viral replication, and while PA-X targets a broad range of RNAs, viral RNAs are protected from its endonuclease activity through their assembly into vRNP complexes.
K. Oishi, Kaori Sano, S. Yamayoshi et al.· Cell Reports· 0 citations
Overall, NIID-002 fulfills the key requirements for the pandemic preparedness of CVV, combining reduced pathogenicity, broad antigenic reactivity, and adequate production efficiency, which underscores the continued need for surveillance and refinement of influenza vaccine strategies to address evolving viral threats.
BA.3.3.2.2 preserves class 1/2 antibody epitopes, providing a mechanistic basis for cross-neutralization and suggesting a potential therapeutic window for sipavibart should BA.3.3.2.2 expand globally, pending clinical confirmation.
Kei Miyakawa, Kaori Sano, Yohei Seki et al.· International Journal of Inf...· 0 citations
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