Open access
Oct 2026
The ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice
Type 2 diabetes is a complex metabolic disease with a strong genetic component, yet this genetic risk is driven by common variants in up to 600 loci with small effect sizes. Variants in the STEAP2 locus, encoding ‘Six-transmembrane epithelial antigen of the prostate-2’, are highly associated with altered glycemic trait...
Avery Hawthorne, Kai Kelly, Mark Tigue et al.
· bioRxiv · 0 citations