Open access
Dec 2025
Engineering a ribozyme with aminoacyl-tRNA synthetase activity
A ribozyme that can charge a tRNA with amino acids and discriminate between cognate and non-cognate tRNAs is of interest because an RNA with this ability may have been a critical for translation in the transition from the RNA world. In addition, it could provide a tool for incorporating non-canonical amino acids for bi...
R. Gan, Ji Chen, Gerald Manuel et al.
· bioRxiv · 0 citations