Hiral M. Sanghavi

Evolutionarily distinct binding of amino-terminal hotspots of the human THAP protein family and its homologs

The THAP (Thanatos-associated protein) domain is a DNA-binding domain which binds DNA via a zinc-coordinating C2CH motif. Although THAP domains share a conserved structural fold, they bind different DNA sequences in different THAP proteins which in turn perform distinct cellular functions. In this study, we investigate...