Open access
Oct 2026
High‐Fat Diet–Induced Metabolic Stress Durably Reprograms the Liver Regenerative Compartment Toward a Senescence‐Like State
ABSTRACT Chronic metabolic stress is increasingly recognized as a driver of aging‐like tissue dysfunction, but whether it durably reprograms liver regenerative cells, potentially compromising tissue maintenance and repair, remains unknown. Here, we show that high‐fat diet (HFD)–induced metabolic stress promotes a persi...
Mirai Yamazaki, Hiroya Yamada, Eiji Munetsuna et al.
· Aging Cell · 0 citations