Oct 2026
IL-12-producing iPSC-derived antigen-presenting cells enhance antitumor immunity and enable off-the-shelf immunotherapy.
Effective activation of cancer-reactive T cells by antigen-presenting cells (APCs) is essential for tumor elimination. However, dendritic cell (DC)-based cancer vaccines often yield inconsistent clinical outcomes due to patient-dependent variability. We established IL-12-producing proliferative myeloid cells (IL12-pMCs...
Masateru Yamamoto, Rong Zhang, Tsuyoshi Kobayashi et al.
· Molecular Therapy · 0 citations